7wwg

Structural highlights

Function

[CSR1_YEAST] Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. Inhibits fatty acid synthase activity in response to heme depletion and oleic acid starvation, preventing saturated fatty acid (SFA) accumulation (PubMed:17803462).^{[1] [2] [3] [4] [5] [6] [7] [8]}

References

1. ↑ Santos B, Snyder M. Sbe2p and sbe22p, two homologous Golgi proteins involved in yeast cell wall formation. Mol Biol Cell. 2000 Feb;11(2):435-52. PMID:10679005
2. ↑ Li X, Routt SM, Xie Z, Cui X, Fang M, Kearns MA, Bard M, Kirsch DR, Bankaitis VA. Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth. Mol Biol Cell. 2000 Jun;11(6):1989-2005. PMID:10848624
3. ↑ Regnacq M, Ferreira T, Puard J, Berges T. SUT1 suppresses sec14-1 through upregulation of CSR1 in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2002 Nov 5;216(2):165-70. doi:, 10.1111/j.1574-6968.2002.tb11431.x. PMID:12435498 doi:http://dx.doi.org/10.1111/j.1574-6968.2002.tb11431.x
4. ↑ Cha MK, Hong SK, Oh YM, Kim IH. The protein interaction of Saccharomyces cerevisiae cytoplasmic thiol peroxidase II with SFH2p and its in vivo function. J Biol Chem. 2003 Sep 12;278(37):34952-8. doi: 10.1074/jbc.M301819200. Epub 2003 , Jun 24. PMID:12824182 doi:http://dx.doi.org/10.1074/jbc.M301819200
5. ↑ Schnabl M, Oskolkova OV, Holic R, Brezna B, Pichler H, Zagorsek M, Kohlwein SD, Paltauf F, Daum G, Griac P. Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover. Eur J Biochem. 2003 Aug;270(15):3133-45. PMID:12869188
6. ↑ Wong TA, Fairn GD, Poon PP, Shmulevitz M, McMaster CR, Singer RA, Johnston GC. Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12777-82. doi:, 10.1073/pnas.0506156102. Epub 2005 Aug 26. PMID:16126894 doi:http://dx.doi.org/10.1073/pnas.0506156102
7. ↑ Routt SM, Ryan MM, Tyeryar K, Rizzieri KE, Mousley C, Roumanie O, Brennwald PJ, Bankaitis VA. Nonclassical PITPs activate PLD via the Stt4p PtdIns-4-kinase and modulate function of late stages of exocytosis in vegetative yeast. Traffic. 2005 Dec;6(12):1157-72. doi: 10.1111/j.1600-0854.2005.00350.x. PMID:16262726 doi:http://dx.doi.org/10.1111/j.1600-0854.2005.00350.x
8. ↑ Desfougeres T, Ferreira T, Berges T, Regnacq M. SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion. Biochem J. 2008 Jan 1;409(1):299-309. doi: 10.1042/BJ20071028. PMID:17803462 doi:http://dx.doi.org/10.1042/BJ20071028