3uom

Structural highlights

Function

CASQ1_HUMAN Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.^{[1] [2]}

References

1. ↑ Sanchez EJ, Lewis KM, Danna BR, Kang C. High-capacity Ca2+-binding of human skeletal calsequestrin. J Biol Chem. 2012 Feb 15. PMID:22337878 doi:10.1074/jbc.M111.335075
2. ↑ Sanchez EJ, Lewis KM, Danna BR, Kang C. High-capacity Ca2+-binding of human skeletal calsequestrin. J Biol Chem. 2012 Feb 15. PMID:22337878 doi:10.1074/jbc.M111.335075