Structural highlights
Function
HIKES_HUMAN Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.[1]
References
- ↑ Kose S, Furuta M, Imamoto N. Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage. Cell. 2012 Apr 27;149(3):578-89. doi: 10.1016/j.cell.2012.02.058. PMID:22541429 doi:http://dx.doi.org/10.1016/j.cell.2012.02.058
