4ehu

Structural highlights

Function

HADI_CLODI Involved in the reductive branch of L-leucine fermentation. Required for the activation of (R)-2-hydroxyisocaproyl-CoA dehydratase. The reduced activator transfers one electron to the dehydratase concomitant with hydrolysis of ATP. This protein is extremely sensitive towards oxygen.^{[1] [2]}

References

1. ↑ Kim J, Darley D, Buckel W. 2-Hydroxyisocaproyl-CoA dehydratase and its activator from Clostridium difficile. FEBS J. 2005 Jan;272(2):550-61. doi: 10.1111/j.1742-4658.2004.04498.x. PMID:15654892 doi:http://dx.doi.org/10.1111/j.1742-4658.2004.04498.x
2. ↑ Knauer SH, Buckel W, Dobbek H. On the ATP-dependent Activation of the Radical Enzyme (R)-2-Hydroxyisocaproyl-CoA Dehydratase. Biochemistry. 2012 Jul 24. PMID:22827463 doi:10.1021/bi300571z