Structural highlights
Disease
GATA3_HUMAN Precursor B-cell acute lymphoblastic leukemia;Hypoparathyroidism - deafness - renal disease. The disease is caused by mutations affecting the gene represented in this entry.
Function
GATA3_HUMAN Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.[1]
References
- ↑ Sasaki T, Onodera A, Hosokawa H, Watanabe Y, Horiuchi S, Yamashita J, Tanaka H, Ogawa Y, Suzuki Y, Nakayama T. Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity. PLoS One. 2013 Jun 18;8(6):e66468. Print 2013. PMID:23824597 doi:http://dx.doi.org/10.1371/journal.pone.0066468
