Structural insights
linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI6-FnII1-2-FnI7-9 is the gelatin binding domain (GBD).
This is a test, , of FN.
Function
Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It plays an important role in cell adhesion, migration and differentiation[1][2]. In addition, Fn is also important for the adherence of pathogens to host tissues and the linking between proteins and cells[3].
Relevance
Fn is associated with wound healing. Fn is a potential marker for radiation resistance.
Disease
Overexpression of Fn1 is associated with lung cancer[4].
3D Structures of Fibronectin
Fibronectin 3D structures
