Structural highlights
2itb is a 2 chain structure with sequence from Pseudomonas putida KT2440. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.05Å |
| Ligands: | , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN |
Function
MIAE_PSEPK Involved in specific tRNA modification. Catalyzes the oxygen-dependent hydroxylation of 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) to produce 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A) at position 37 in tRNAs.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Carpentier P, Lepretre C, Basset C, Douki T, Torelli S, Duarte V, Hamdane D, Fontecave M, Atta M. Structural, biochemical and functional analyses of tRNA-monooxygenase enzyme MiaE from Pseudomonas putida provide insights into tRNA/MiaE interaction. Nucleic Acids Res. 2020 Aug 12. pii: 5891576. doi: 10.1093/nar/gkaa667. PMID:32785618 doi:http://dx.doi.org/10.1093/nar/gkaa667
