Structural highlights
4ojz is a 2 chain structure with sequence from Saccharophagus degradans 2-40. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.9Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
EALGL_SACD2 Catalyzes the depolymerization of alginate through an exolytic mode of action, via a beta-elimination mechanism. Preferentially acts on oligoalginates with degrees of polymerization higher than 2 to produce the alginate monomer, 4-deoxy-L-erythro-5-hexoseulose uronic acid.[1] [2]
References
- ↑ Kim HT, Chung JH, Wang D, Lee J, Woo HC, Choi IG, Kim KH. Depolymerization of alginate into a monomeric sugar acid using Alg17C, an exo-oligoalginate lyase cloned from Saccharophagus degradans 2-40. Appl Microbiol Biotechnol. 2012 Mar;93(5):2233-9. doi: 10.1007/s00253-012-3882-x. , Epub 2012 Jan 27. PMID:22281843 doi:http://dx.doi.org/10.1007/s00253-012-3882-x
- ↑ Park D, Jagtap S, Nair SK. Structure of a PL17 Family Alginate Lyase Demonstrates Functional Similarities among Exotype Depolymerases. J Biol Chem. 2014 Mar 21;289(12):8645-55. doi: 10.1074/jbc.M113.531111. Epub 2014, Jan 29. PMID:24478312 doi:http://dx.doi.org/10.1074/jbc.M113.531111
