7wla

Structural highlights

Function

S26A4_MOUSE Sodium-independent transporter of chloride and iodide (By similarity). Mediates electroneutral iodide-chloride, iodide-bicarbonate and chloride-bicarbonate exchange with 1:1 stoichiometry (PubMed:11274445, PubMed:18565999). Mediates elctroneutral chloride-formate exchange (By similarity).[UniProtKB:Q9R154]^{[1] [2]}

References

1. ↑ Royaux IE, Wall SM, Karniski LP, Everett LA, Suzuki K, Knepper MA, Green ED. Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4221-6. PMID:11274445 doi:10.1073/pnas.071516798
2. ↑ Shcheynikov N, Yang D, Wang Y, Zeng W, Karniski LP, So I, Wall SM, Muallem S. The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3 J Physiol. 2008 Aug 15;586(16):3813-24. PMID:18565999 doi:10.1113/jphysiol.2008.154468