4x7y

Structural highlights

Function

MYCF_MICGR O-methyltransferase that catalyzes the conversion of mycinamicin III to mycinamicin IV in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic.^{[1] [2] [3]}

References

1. ↑ Li S, Anzai Y, Kinoshita K, Kato F, Sherman DH. Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics. Chembiochem. 2009 May 25;10(8):1297-301. doi: 10.1002/cbic.200900088. PMID:19415708 doi:http://dx.doi.org/10.1002/cbic.200900088
2. ↑ Inouye M, Takada Y, Muto N, Beppu T, Horinouchi S. Characterization and expression of a P-450-like mycinamicin biosynthesis gene using a novel Micromonospora-Escherichia coli shuttle cosmid vector. Mol Gen Genet. 1994 Nov 15;245(4):456-64. PMID:7808395
3. ↑ Inouye M, Suzuki H, Takada Y, Muto N, Horinouchi S, Beppu T. A gene encoding mycinamicin III O-methyltransferase from Micromonospora griseorubida. Gene. 1994 Apr 8;141(1):121-4. PMID:8163162