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1jsu

From Proteopedia

Revision as of 11:26, 21 February 2008 by OCA (Talk | contribs)
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Image:1jsu.gif

1jsu, resolution 2.3Å

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P27(KIP1)/CYCLIN A/CDK2 COMPLEX

Contents

Overview

The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.

Disease

Known diseases associated with this structure: Multiple endocrine neoplasia, type IV OMIM:[600778]

About this Structure

1JSU is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:8684460

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