8sh7

Structural highlights

Disease

TBA1A_HUMAN Lissencephaly due to TUBA1A mutation. The disease is caused by mutations affecting the gene represented in this entry.

Function

TBA1A_HUMAN Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.