5gpq

Structural highlights

Function

ASC_DANRE Functions as key mediator in apoptosis and inflammation (PubMed:12464617, PubMed:30150286). Promotes caspase-mediated apoptosis (PubMed:12464617). Induces proteolytic processing of caspa and caspa-dependent apoptosis (PubMed:12464617). Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines (PubMed:30150286). Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death (By similarity). The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions (PubMed:30150286). Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization (By similarity). Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome (By similarity).[UniProtKB:Q9ULZ3]^{[1] [2]} MALE_ECOLI Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.

References

1. ↑ Masumoto J, Zhou W, Chen FF, Su F, Kuwada JY, Hidaka E, Katsuyama T, Sagara J, Taniguchi S, Ngo-Hazelett P, Postlethwait JH, Núñez G, Inohara N. Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development. J Biol Chem. 2003 Feb 7;278(6):4268-76. PMID:12464617 doi:10.1074/jbc.M203944200
2. ↑ Li JY, Gao K, Shao T, Fan DD, Hu CB, Sun CC, Dong WR, Lin AF, Xiang LX, Shao JZ. Characterization of an NLRP1 Inflammasome from Zebrafish Reveals a Unique Sequential Activation Mechanism Underlying Inflammatory Caspases in Ancient Vertebrates. J Immunol. 2018 Oct 1;201(7):1946-1966. PMID:30150286 doi:10.4049/jimmunol.1800498