Structural highlights
Function
HPNN_BURM1 Essential for hopanoid transport from the cytoplasmic to the outer membrane (PubMed:28584102). Is capable of shuttling hopanoid lipids from the inner membrane to the periplasm, where they probably spontaneously insert to the inner leaflet of the outer membrane, strengthening the cell envelope (PubMed:28584102). May be a proton-motive-force (PMF)-dependent transporter (PubMed:28584102). Is critical for multidrug resistance and cell wall remodeling in Burkholderia (PubMed:28584102).[1]
References
- ↑ Kumar N, Su CC, Chou TH, Radhakrishnan A, Delmar JA, Rajashankar KR, Yu EW. Crystal structures of the Burkholderia multivorans hopanoid transporter HpnN. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6557-6562. doi:, 10.1073/pnas.1619660114. Epub 2017 Jun 5. PMID:28584102 doi:http://dx.doi.org/10.1073/pnas.1619660114
