1nql

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Template:STRUCTURE 1nql

Contents

Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.

Template:ABSTRACT PUBMED 12620237

Disease

Known disease associated with this structure: Hypomagnesemia 4, renal OMIM:[131530]

About this Structure

1NQL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization., Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA, Mol Cell. 2003 Feb;11(2):507-17. PMID:12620237

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