1wt6

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Image:1wt6.gif

1wt6, resolution 1.60Å

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Coiled-Coil domain of DMPK

Contents

Overview

The coiled-coil domain of dystrophia myotonica protein kinase (DMPK) has been cloned, overexpressed, purified and crystallized. Two crystal forms have been obtained that belong to space groups P3 and P2(1)2(1)2(1) and diffract to 2.4 and 1.6 A resolution, respectively. Experimental phases were obtained by MAD from an SeMet derivative. The location of selenium sites used molecular-replacement phases obtained from search models lacking sequence similarity with the coiled-coil under study. Both crystal forms contain three polypeptide chains in the asymmetric unit.

Disease

Known disease associated with this structure: Myotonic dystrophy OMIM:[605377]

About this Structure

1WT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase., Garcia P, Marino M, Mayans O, Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2336-9. Epub, 2004 Nov 26. PMID:15583383

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