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Structural highlights

Disease

TOM40_HUMAN Early-onset autosomal dominant Alzheimer disease.

Function

TOM40_HUMAN Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022).^{[1] [2]}

References

1. ↑ Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ, Ryan MT. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005 Mar 25;280(12):11535-43. PMID:15644312 doi:10.1074/jbc.M413816200
2. ↑ Namba T. BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. Sci Adv. 2019 Jun 12;5(6):eaaw1386. PMID:31206022 doi:10.1126/sciadv.aaw1386