Structural highlights
Function
OSCRI_HUMAN Represses translation of the downstream SCRIB protein (PubMed:34535749). Translation of oSCRIB hinders SCRIB translation but does not completely abolish it, probably due to leaky scanning which allows the ribosome to bypass the weaker oSCRIB start codon and initiate translation at the stronger SCRIB start codon (PubMed:34535749).[1]
References
- ↑ Nomura Y, Dohmae N. Discovery of a small protein-encoding cis-regulatory overlapping gene of the tumor suppressor gene Scribble in humans. Commun Biol. 2021 Sep 17;4(1):1098. PMID:34535749 doi:10.1038/s42003-021-02619-8
