Structural highlights
Function
NFIX_MOUSE Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Isoform NFIX1 acts as a transcriptional activator while isoform NFIX3 acts as a repressor.[1]
References
- ↑ Nebl G, Cato AC. NFI/X proteins: a class of NFI family of transcription factors with positive and negative regulatory domains. Cell Mol Biol Res. 1995;41(2):85-95 PMID:8581067
