From Proteopedia
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The ice formation of water (red spheres) being scrambled (blue spheres) by the protein
Threonines and Aspartates are lined up in a manner that binds nearby water molecules in a manner that is off-set from the ice crystal lattice
Marinomonas primoryensis
Structural highlights
References
Garnham, Christopher P., Robert L. Campbell, and Peter L. Davies. "Anchored clathrate waters bind antifreeze proteins to ice." Proceedings of the National Academy of Sciences 108.18 (2011): 7363-7367.