9sa7

Structural highlights

Function

MDH_METJA Catalyzes the reversible oxidation of malate to oxaloacetate. Also catalyzes the reduction of sulfopyruvate, but not pyruvate, nor alpha-ketoglutarate. Higher selectivity for the coenzyme NADPH.^{[1] [2]}

References

1. ↑ Graupner M, Xu H, White RH. Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea. J Bacteriol. 2000 Jul;182(13):3688-92. PMID:10850983
2. ↑ Madern D. The putative L-lactate dehydrogenase from Methanococcus jannaschii is an NADPH-dependent L-malate dehydrogenase. Mol Microbiol. 2000 Sep;37(6):1515-20. PMID:10998181