Sandbox 46

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Template:STRUCTURE 1w68 Template:STRUCTURE 1w69

Contents 1 Mouse Ribonucleotide Reductase 2 Introduction 3 Structual Properties 4 Protein Sequence 5 This is a placeholder

Mouse Ribonucleotide Reductase

Protein ID:

1w68 (under oxidizing conditions)

1w69 (under reducing conditions)

Introduction

Structual Properties

While both forms of this enzyme both interact with iron, there are some structural differences due to the different conditions.

1w68: 16 α-helices 8 β-turns

1w69: 15 α-helices 10 β-turns

Protein Sequence

For the enzyme under oxidizing conditions (1w68):

VEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFA ASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVK KKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFA CLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFR VENPF

For the enzyme under reducing conditions(1w69):

VEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFA ASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVK KKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFA CLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFR VENPF

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