3cds
From Proteopedia
Crystal structure of the complex between PPAR-gamma and the agonist LT248 (clofibric acid analogue)
Template:ABSTRACT PUBMED 19053776
About this Structure
3CDS is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design., Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G, J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors., Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT Jr, McKee DD, Moore JT, Willson TM, Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24. Epub 2001 Nov 6. PMID:11698662
Page seeded by OCA on Wed Dec 31 10:18:38 2008
Categories: Homo sapiens | Mazza, F. | Montanari, R. | Pochetti, G. | Activator | Alternative splicing | Bundle of alpha-helices and a small four-stranded beta-sheet | Diabetes mellitus | Disease mutation | Dna-binding | Metal-binding | Nucleus | Obesity | Phosphoprotein | Polymorphism | Receptor | Transcription | Transcription regulation | Zinc | Zinc-finger
