Sandbox 3

From Proteopedia

Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) with the bisquaternary ligand decamethonium (DME). DME is oriented along the narrow gorge leading to the active site; one quaternary group is apposed to the indole of W84 and the other to that of W279, near the top of the gorge, i.e. the "peripheral" anionic site. The only major conformational change in the structure AChE is in the orientation of F330 which lies parallel to the surface of the gorge, near the cationic binding site of AChE which contains the catalytic triad S200, E327 & H440.