1gi9
From Proteopedia
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Template:ABSTRACT PUBMED 11292354
About this Structure
1GI9 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J Mol Biol. 2001 Apr 13;307(5):1451-86. PMID:11292354 doi:http://dx.doi.org/10.1006/jmbi.2001.4516
Page seeded by OCA on Mon Feb 16 11:54:44 2009
Categories: Homo sapiens | U-plasminogen activator | Elrod, K. | Hatayte, J. | Janc, J. | Katz, B A. | Link, J. | Litvak, J. | Luong, C. | Mackman, R L. | Rai, R. | Rice, K. | Rice, M. | Sideris, S. | Spencer, J. | Sprengeler, P A. | Verner, E. | Young, W. | Oxyanion hole water | Shift of pka of his57 | Specificity | Structure-based drug design | Three-centered | Thrombin | Trypsin | Urokinase | Very short hydrogen bond | Zn+2-mediated inhibition