1h6v

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spinqualitylabelsall models PDB ID 1h6v Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1h6v, resolution 3.00Å ()
Ligands:	,
Non-Standard Residues:
Activity:	Thioredoxin-disulfide reductase, with EC number 1.8.1.9
Structural annotation: Resources: CATH : 1H6Va03, 1H6Va01, 1H6Va02, 1H6Vb03, 1H6Vb01, 1H6Vb02, 1H6Vc01, 1H6Vc02, 1H6Vc03, 1H6Vd01, 1H6Vd02, 1H6Vd03, 1H6Ve01, 1H6Ve02, 1H6Ve03, 1H6Vf01, 1H6Vf02, 1H6Vf03 InterPro : Ipr004099, Ipr012999, Ipr001100, Ipr006338, Ipr013027, Ipr001327, Ipr000815 Pfam : PF02852, PF00070, PF07992 SCOP : d1h6va1, d1h6va3, d1h6va2, d1h6vb1, d1h6vb2, d1h6vb3, d1h6vc3, d1h6vc1, d1h6vc2, d1h6vd1, d1h6vd2, d1h6vd3, d1h6ve1, d1h6ve3, d1h6ve2, d1h6vf1, d1h6vf3, d1h6vf2 UniProt : O89049
Functional annotation: Cellular component: cytosol cytoplasm Biological process: cell proliferation electron transport response to oxidative stress hydrogen peroxide catabolic process cell redox homeostasis thioredoxin pathway Molecular function: NADP binding FAD binding thioredoxin-disulfide reductase activity oxidoreductase activity selenium binding oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

MAMMALIAN THIOREDOXIN REDUCTASE

Template:ABSTRACT PUBMED 11481439

About this Structure

1H6V is a 6 chains structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

• Sandalova T, Zhong L, Lindqvist Y, Holmgren A, Schneider G. Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9533-8. Epub 2001 Jul 31. PMID:11481439 doi:10.1073/pnas.171178698

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