1j7s

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Image:1j7s.png

Template:STRUCTURE 1j7s

Contents

Crystal Structure of deoxy HbalphaYQ, a mutant of HbA

Template:ABSTRACT PUBMED 11724557

Disease

Known disease associated with this structure: Erythremias, alpha- OMIM:[141800], Heinz body anemias, alpha- OMIM:[141800], Methemoglobinemias, alpha- OMIM:[141800], Thalassemias, alpha- OMIM:[141800], Erythremias, beta- OMIM:[141900], Heinz body anemias, beta- OMIM:[141900], Hereditary persistence of fetal hemoglobin OMIM:[141900], Methemoglobinemias, beta- OMIM:[141900], Sickle cell anemia OMIM:[141900], Thalassemia-beta, dominant inclusion-body OMIM:[141900], Thalassemias, beta- OMIM:[141900]

About this Structure

1J7S is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Miele AE, Draghi F, Arcovito A, Bellelli A, Brunori M, Travaglini-Allocatelli C, Vallone B. Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants. Biochemistry. 2001 Dec 4;40(48):14449-58. PMID:11724557

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