2qe5

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Image:2qe5.png

Template:STRUCTURE 2qe5

Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor

Template:ABSTRACT PUBMED 17402724

About this Structure

2QE5 is a 4 chains structure of sequences from Hepatitis c virus subtype 1b. Full crystallographic information is available from OCA.

Reference

  • Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J. Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase. J Med Chem. 2007 May 3;50(9):2108-16. Epub 2007 Apr 3. PMID:17402724 doi:10.1021/jm061428x

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