1rr8

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Image:1rr8.png

Template:STRUCTURE 1rr8

Contents

Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I

Template:ABSTRACT PUBMED 15165849

Disease

Known disease associated with this structure: DNA topoisomerase I, camptothecin-resistant OMIM:[126420]

About this Structure

1RR8 is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR. Mechanisms of camptothecin resistance by human topoisomerase I mutations. J Mol Biol. 2004 Jun 11;339(4):773-84. PMID:15165849 doi:http://dx.doi.org/10.1016/j.jmb.2004.03.077

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