2p8s

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Image:2p8s.png

Template:STRUCTURE 2p8s

Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor

Template:ABSTRACT PUBMED 17433672

About this Structure

2P8S is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Biftu T, Scapin G, Singh S, Feng D, Becker JW, Eiermann G, He H, Lyons K, Patel S, Petrov A, Sinha-Roy R, Zhang B, Wu J, Zhang X, Doss GA, Thornberry NA, Weber AE. Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3384-7. Epub 2007 Apr 2. PMID:17433672 doi:10.1016/j.bmcl.2007.03.095

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