3b2w

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Image:3b2w.png

Template:STRUCTURE 3b2w

Contents

Crystal structure of pyrimidine amide 11 bound to Lck

Template:ABSTRACT PUBMED 18083554

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3B2W is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Deak HL, Newcomb JR, Nunes JJ, Boucher C, Cheng AC, DiMauro EF, Epstein LF, Gallant P, Hodous BL, Huang X, Lee JH, Patel VF, Schneider S, Turci SM, Zhu X. N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1172-6. Epub 2007 Dec 5. PMID:18083554 doi:http://dx.doi.org/10.1016/j.bmcl.2007.11.123

Page seeded by OCA on Mon Feb 16 18:35:55 2009

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