1nwe

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Image:1nwe.png

Template:STRUCTURE 1nwe

Contents

Ptp1B R47C Modified at C47 with N-[4-(2-{2-[3-(2-Bromo-acetylamino)-propionylamino]-3-hydroxy-propionylamino}-ethyl)-phenyl]-oxalamic acid

Template:ABSTRACT PUBMED 12733877

Disease

Known disease associated with this structure: Insulin resistance, susceptibility to OMIM:[176885]

About this Structure

1NWE is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Erlanson DA, McDowell RS, He MM, Randal M, Simmons RL, Kung J, Waight A, Hansen SK. Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering. J Am Chem Soc. 2003 May 14;125(19):5602-3. PMID:12733877 doi:10.1021/ja034440c

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