2rl5

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Image:2rl5.png

Template:STRUCTURE 2rl5

Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor

Template:ABSTRACT PUBMED 18311900

About this Structure

2RL5 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • La DS, Belzile J, Bready JV, Coxon A, Demelfi T, Doerr N, Estrada J, Flynn JC, Flynn SR, Graceffa RF, Harriman SP, Larrow JF, Long AM, Martin MW, Morrison MJ, Patel VF, Roveto PM, Wang L, Weiss MM, Whittington DA, Teffera Y, Zhao Z, Polverino AJ, Harmange JC. Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis. J Med Chem. 2008 Mar 27;51(6):1695-705. Epub 2008 Feb 27. PMID:18311900 doi:10.1021/jm701129j

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