1zml

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Template:STRUCTURE 1zml

Contents 1 Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine 2 Disease 3 About this Structure 4 Reference

Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl)guanidine

Template:ABSTRACT PUBMED 16876411

Disease

Known disease associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[264900], Factor XI deficiency, autosomal recessive OMIM:[264900]

About this Structure

1ZML is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Lazarova TI, Jin L, Rynkiewicz M, Gorga JC, Bibbins F, Meyers HV, Babine R, Strickler J. Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5022-7. Epub 2006 Jul 28. PMID:16876411 doi:http://dx.doi.org/10.1016/j.bmcl.2006.07.043

Page seeded by OCA on Tue Feb 17 13:15:23 2009