1r1w

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spinqualitylabelsall models PDB ID 1r1w Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1r1w, resolution 1.80Å ()
Gene:	MET (Homo sapiens)
Activity:	Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Related:	1r0p
Structural annotation: Resources: CATH : 1R1Wa02, 1R1Wa01 InterPro : Ipr003659, Ipr014756, Ipr002909, Ipr000719, Ipr008266, Ipr002165, Ipr001627, Ipr001245, Ipr011009 Pfam : PF07714 SCOP : d1r1wa_ UniProt : P08581
Functional annotation: Cellular component: membrane fraction integral to membrane membrane integral to plasma membrane basal plasma membrane Biological process: multicellular organismal development cell surface receptor linked signal transduction protein amino acid autophosphorylation cell proliferation brain development adult behavior activation of MAPK activity signal transduction protein amino acid phosphorylation hepatocyte growth factor receptor signaling pathway myoblast proliferation muscle development Molecular function: transferase activity receptor activity nucleotide binding hepatocyte growth factor receptor activity protein-tyrosine kinase activity kinase activity protein binding protein kinase activity ATP binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET 2 Disease 3 About this Structure 4 Reference

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET

Template:ABSTRACT PUBMED 14559966

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

1R1W is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9. Epub 2003 Oct 14. PMID:14559966 doi:10.1073/pnas.1734128100

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