2jmn

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Image:2jmn.png

Template:STRUCTURE 2jmn

Contents

NMR structure of human insulin mutant His-B10-Asp, Pro-B28-Lys, Lys-B29-Pro, 20 structures

Template:ABSTRACT PUBMED 8951384

Disease

Known disease associated with this structure: Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]

About this Structure

2JMN is a 2 chains structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entries and 1vks. Full experimental information is available from OCA.

Reference

  • Hua QX, Hu SQ, Frank BH, Jia W, Chu YC, Wang SH, Burke GT, Katsoyannis PG, Weiss MA. Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue. J Mol Biol. 1996 Nov 29;264(2):390-403. PMID:8951384 doi:10.1006/jmbi.1996.0648

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