This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1w66
From Proteopedia
|
STRUCTURE OF A LIPOATE-PROTEIN LIGASE B FROM MYCOBACTERIUM TUBERCULOSIS
Overview
Lipoic acid is essential for the activation of a number of protein, complexes involved in key metabolic processes. Growth of Mycobacterium, tuberculosis relies on a pathway in which the lipoate attachment group is, synthesized from an endogenously produced octanoic acid moiety. In, patients with multiple-drug-resistant M. tuberculosis, expression of one, gene from this pathway, lipB, encoding for octanoyl-[acyl carrier, protein]-protein acyltransferase is considerably up-regulated, thus making, it a potential target in the search for novel antiinfectives against, tuberculosis. Here we present the crystal structure of the M. tuberculosis, LipB protein at atomic resolution, showing an unexpected thioether-linked, active-site complex with decanoic acid. We provide evidence that the, ... [(full description)]
About this Structure
1W66 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with DKA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase., Ma Q, Zhao X, Nasser Eddine A, Geerlof A, Li X, Cronan JE, Kaufmann SH, Wilmanns M, Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8662-7. Epub 2006 May 30. PMID:16735476
Page seeded by OCA on Tue Oct 30 13:50:28 2007
Categories: Mycobacterium tuberculosis | Single protein | Ma, Q. | Wilmanns, M. | XMTB, Mycobacterium.Tuberculosis.Structural.Proteomics.Project. | DKA | Acyltransferase | Lipoate-protein ligase b | Lipoic acid | Lipoyltransferase | Mycobacterium tuberculosis structural proteomics project | Structural genomics | Transferase | Xmtb
