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1tnd
From Proteopedia
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THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S
Overview
The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data.
About this Structure
1TND is a Single protein structure of sequence from Bos taurus with , and as ligands. Full crystallographic information is available from OCA.
Reference
The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S., Noel JP, Hamm HE, Sigler PB, Nature. 1993 Dec 16;366(6456):654-63. PMID:8259210
Page seeded by OCA on Thu Feb 21 15:15:22 2008
Categories: Bos taurus | Single protein | Hamm, H E. | Noel, J P. | Sigler, P B. | CAC | GSP | MG | Binding protein(gtp)
