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3ela
From Proteopedia
Contents |
Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor
Template:ABSTRACT PUBMED 18640965
Disease
Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
3ELA is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bjelke JR, Olsen OH, Fodje M, Svensson LA, Bang S, Bolt G, Kragelund BB, Persson E. Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity. J Biol Chem. 2008 Sep 19;283(38):25863-70. Epub 2008 Jul 17. PMID:18640965 doi:10.1074/jbc.M800841200
Page seeded by OCA on Tue Feb 17 12:17:26 2009
Categories: Coagulation factor VIIa | Homo sapiens | Bjelke, J R. | Fodje, M. | Svensson, L A. | Allosteric regulation | Allostery | Alternative splicing | Blood clotting | Blood coagulation | Calcium | Cleavage on pair of basic residue | Disease mutation | Egf-like domain | Exosite | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Hydroxylation | Lipoprotein | Membrane | Palmitate | Pharmaceutical | Polymorphism | Protease | Secreted | Serine protease | Transmembrane | Zymogen
