2zm4
From Proteopedia
Contents |
Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394)
Template:ABSTRACT PUBMED 18977146
Disease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this Structure
2ZM4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase., Ozawa T, Tsuji E, Ozawa M, Handa C, Mukaiyama H, Nishimura T, Kobayashi S, Okazaki K, Bioorg Med Chem. 2008 Dec 15;16(24):10311-8. Epub 2008 Oct 22. PMID:18977146[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
Page seeded by OCA on Wed Feb 4 20:05:25 2009
Categories: Homo sapiens | Non-specific protein-tyrosine kinase | Single protein | Alternative splicing | Atp-binding | Chromosomal rearrangement | Cytoplasm | Disease mutation | Host-virus interaction | Lipoprotein | Membrane | Myristate | Nucleotide-binding | Palmitate | Phosphoprotein | Phosphorylation | Proto-oncogene | Sh2 domain | Sh3 domain | Signal transduction | Transferase | Tyrosine-protein kinase