3b2v
From Proteopedia
Contents |
Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Template:ABSTRACT PUBMED 18275813
Disease
Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]
About this Structure
3B2V is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Li S, Kussie P, Ferguson KM. Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. Structure. 2008 Feb;16(2):216-27. PMID:18275813 doi:10.1016/j.str.2007.11.009
Page seeded by OCA on Sun Mar 22 10:49:49 2009
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Ferguson, K M. | Kussie, P. | Li, S. | Alternative splicing | Anti-oncogene | Antigen:antibody complex | Antitumor | Atp-binding | Cell cycle | Cell surface receptor | Disease mutation | Drug | Fab fragment | Glycoprotein | Immune system/transferase complex | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Polymorphism | Secreted | Transferase | Transmembrane | Tyrosine-protein kinase | Ubl conjugation
