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2pjy

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Revision as of 06:56, 17 March 2010 by OCA (Talk | contribs)
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Image:2pjy.png

Template:STRUCTURE 2pjy

Contents

Structural basis for cooperative assembly of the TGF-beta signaling complex

Template:ABSTRACT PUBMED 18243111

Disease

Known disease associated with this structure: Arrhythmogenic right ventricular dysplasia 1 OMIM:[190230], Colorectal cancer, hereditary nonpolyposis, type 6 OMIM:[190182], Esophageal cancer OMIM:[190182], Loeys-Dietz syndrome, type 1B OMIM:[190182], Loeys-Dietz syndrome, type 2B OMIM:[190182], Loeys-Dietz syndrome, type 1A OMIM:[190181], Loeys-Dietz syndrome, type 2A OMIM:[190181]

About this Structure

2PJY is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Groppe J, Hinck CS, Samavarchi-Tehrani P, Zubieta C, Schuermann JP, Taylor AB, Schwarz PM, Wrana JL, Hinck AP. Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol Cell. 2008 Feb 1;29(2):157-68. PMID:18243111 doi:10.1016/j.molcel.2007.11.039

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