1o4x

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Image:1o4x.png

Template:STRUCTURE 1o4x

Contents

TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT

Template:ABSTRACT PUBMED 14559893

Disease

Known disease associated with this structure: Microphthalmia, syndromic 3 OMIM:[184429], Optic nerve hypoplasia and abnormalities of the central nervous system OMIM:[184429]

About this Structure

1O4X is a 4 chains structure of sequences from Homo sapiens. The April 2009 RCSB PDB Molecule of the Month feature on Oct and Sox Transcription Factors by David Goodsell is 10.2210/rcsb_pdb/mom_2009_04. Full experimental information is available from OCA.

Reference

  • Williams DC Jr, Cai M, Clore GM. Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex. J Biol Chem. 2004 Jan 9;279(2):1449-57. Epub 2003 Oct 14. PMID:14559893 doi:http://dx.doi.org/10.1074/jbc.M309790200

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