1pv8

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Image:1pv8.png

Template:STRUCTURE 1pv8

Contents

Crystal structure of a low activity F12L mutant of human porphobilinogen synthase

Template:ABSTRACT PUBMED 12897770

Disease

Known disease associated with this structure: Porphyria, acute hepatic OMIM:[125270], Lead poisoning, susceptibility to OMIM:[125270]

About this Structure

1PV8 is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, Zdanov A, Jaffe EK. Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase. Nat Struct Biol. 2003 Sep;10(9):757-63. Epub 2003 Aug 3. PMID:12897770 doi:10.1038/nsb963

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