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1szm

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Image:1szm.png

Template:STRUCTURE 1szm

DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)

Template:ABSTRACT PUBMED 14996846

About this Structure

1szm is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Gassel M, Breitenlechner CB, Konig N, Huber R, Engh RA, Bossemeyer D. The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. J Biol Chem. 2004 May 28;279(22):23679-90. Epub 2004 Mar 1. PMID:14996846 doi:10.1074/jbc.M314082200
  • Prade L, Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D. Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential. Structure. 1997 Dec 15;5(12):1627-37. PMID:9438863

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OCA

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