1yc2

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Image:1yc2.png

Template:STRUCTURE 1yc2

Sir2Af2-NAD-ADPribose-nicotinamide

Template:ABSTRACT PUBMED 15780941

About this Structure

1yc2 is a 5 chain structure with sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

  • Avalos JL, Bever KM, Wolberger C. Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell. 2005 Mar 18;17(6):855-68. PMID:15780941 doi:10.1016/j.molcel.2005.02.022

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