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1w7j
From Proteopedia
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CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX- NEAR RIGOR
Overview
The molecular motor, myosin, undergoes conformational changes in order to, convert chemical energy into force production. Based on kinetic and, structural considerations, we assert that three crystal forms of the, myosin V motor delineate the conformational changes that myosin motors, undergo upon detachment from actin. First, a motor domain structure, demonstrates that nucleotide-free myosin V adopts a specific state, (rigor-like) that is not influenced by crystal packing. A second structure, reveals an actomyosin state that favors rapid release of ADP, and differs, from the rigor-like state by a P-loop rearrangement. Comparison of these, structures with a third structure, a 2.0 angstroms resolution structure of, the motor bound to an ATP analog, illuminates the structural features that, ... [(full description)]
About this Structure
1W7J is a [Protein complex] structure of sequences from [Gallus gallus] and [Homo sapiens] with MG, ADP and BEF as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Three myosin V structures delineate essential features of chemo-mechanical transduction., Coureux PD, Sweeney HL, Houdusse A, EMBO J. 2004 Nov 24;23(23):4527-37. Epub 2004 Oct 28. PMID:15510214
Page seeded by OCA on Tue Oct 30 14:19:52 2007
Categories: Gallus gallus | Homo sapiens | Protein complex | Coureux, P.D. | Houdusse, A. | Sweeney, H.L. | ADP | BEF | MG | Actin-binding | Atp-binding | Atpase | Calmodulin-binding | Chicken | Direct protein sequencing | Elc | Iq motif | Molecular motor | Muscle protein | Myosin | Myosin v | Phosphorylation | Unconventional myosin
