3cog

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Image:3cog.png

Template:STRUCTURE 3cog

Contents

Crystal structure of human cystathionase (Cystathionine gamma lyase) in complex with DL-propargylglycine

Template:ABSTRACT PUBMED 19019829

Disease

Known disease associated with this structure: Cystathioninuria OMIM:[607657], Homocysteine, total plasma, elevated OMIM:[607657]

About this Structure

3COG is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sun Q, Collins R, Huang S, Holmberg-Schiavone L, Anand GS, Tan CH, van-den-Berg S, Deng LW, Moore PK, Karlberg T, Sivaraman J. Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S. J Biol Chem. 2009 Jan 30;284(5):3076-85. Epub 2008 Nov 19. PMID:19019829 doi:http://dx.doi.org/10.1074/jbc.M805459200

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