3cjc

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Image:3cjc.png

Template:STRUCTURE 3cjc

Contents

Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with DNase I and Gelsolin-segment 1

Template:ABSTRACT PUBMED 19015515

Disease

Known disease associated with this structure: Amyloidosis, Finnish type OMIM:[137350]

About this Structure

3CJC is a 3 chains structure of sequences from Bos taurus, Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

  • Kudryashov DS, Durer ZA, Ytterberg AJ, Sawaya MR, Pashkov I, Prochazkova K, Yeates TO, Loo RR, Loo JA, Satchell KJ, Reisler E. Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18537-42. Epub 2008 Nov 17. PMID:19015515

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