2h3b

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Image:2h3b.gif

2h3b, resolution 1.95Å

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Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1

Overview

Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.

About this Structure

2H3B is a Single protein structure of sequence from Mus musculus with as ligand. Active as Nicotinamide phosphoribosyltransferase, with EC number 2.4.2.12 Full crystallographic information is available from OCA.

Reference

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme., Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C, Nat Struct Mol Biol. 2006 Jul;13(7):661-2. Epub 2006 Jun 18. PMID:16783373

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